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CART Models of Speiser et al for a Patient with Acetaminophen-Induced Acute Liver Failure: Admission Model Based on New Variables

Description

Speiser et al developed several classification and regression tree (CART) models for acetaminophen-induced acute liver failure. One is based on variables different from those of the King's College Hospital available at hospital admission. The authors are from the United States Acute Liver Failure Study Group (ALFSG).


 

Patient selection: acetaminophen-induced acute liver failure

 

Parameters on admission (designated Day 1):

(1) revised MELD score

(2) mechanical ventilation

(3) serum lactate in mmol/L

 

Revised MELD

Mechanical Ventilation

Serum Lactate

Mortality

< 15.5

NA

NA

7%

>= 15.5

no

NA

39%

>= 15.5

yes

< 3.25

27%

>= 15.5

yes

>= 3.25

76%

 

Performance:

• The area under the ROC curve was 0.76 to 0.79.

 


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