Litvan et al identified clinical features that can help distinguish progressive supranuclear palsy (PSP) from corticobasal degeneration (CBD). The authors are from NIH, Massachuesetts General Hospital, Hopital de la Salpetriere (Paris), Ludwig Boltzmann Institute of Clinical Neurobiology (Vienna) and the Institute of Neurology (London).
Analysis: both logistic regression and CART performed
Parameters:
(1) gait abnormality
(2) upward gaze palsy
(3) bilateral bradykinesia
(4) alien limb syndrome
Gait Abnormality
Upward Gaze Palsy
Bilateral Bradykinesia
Alien Limb
Diagnosis
absent
NA
NA
NA
probable CBD (possible PSP)
present
present
NA
NA
probable PSP (rare CBD)
present
absent
absent
NA
CBD
present
absent
present
present
CBD
present
absent
present
absent
probable PSP (possible CBD)
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