A patient with amyloidosis may present with the carpal tunnel syndrome.

Type of amyloidosis: wild-type transthyretin amyloidosis (ATTRwt)


Onset is typically after the age of 60 years.


An affected patient may also develop:

(1) cardiomyopathy with heart failure

(2) spinal stenosis

(3) biceps tendon rupture

(4) renal dysfunction


Diagnosis is made by positive Congo Red staining in a sampling of the tenosynovium.  Additional testing (immunoperoxidase staining for transthyretin, mass spectrometry) can be performed to identify the type of amyloid.


Some patients with tenosynovial amyloidosis do not develop systemic amyloidosis.

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