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Cardiotoxicity and Neurotoxicity Following Infusion of 5-Fluorouracil Prepared in Tris Buffer

Specialty:

Clinical Pharmacology & Toxicology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care

Objective:

ICD-10:

Description:

Patients receiving infusions of 5-fluorouracil (5-FU) prepared in Tris buffer may develop cardiac and/or neurologic toxicity. This is due to the release of toxic metabolites formed in the solution.

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