Description

Gertz et al used cardiac biomarkers to identify patients with light chain amyloidosis who are at increased risk for short-term mortality following autologous stem cell transplantation. These patients should be considered for less toxic therapy. The authors are from the Mayo Clinic.


Patient selection: light chain amyloidosis, not on dialysis

 

Predictors associated with short-term all-cause mortality:

(1) elevated serum troponin concentration (troponin T > 0.06 ng/mL; level of detection 0.01 ng/mL)

(2) elevated serum BNP or NT-proBNP (NT-proBNP > 5,000 pg/mL)

 

It might be interesting to see if cardiac echocardiography could be used to further refine the contraindications.


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