In amyloidosis an abnormal protein is deposited in one or more organs of the body. Deposits in the heart may result in cardiomegaly, heart failure and conduction defects.
Clinical findings:
(1) congestive heart failure, especially without a history of previous heart disease
(2) hepatosplenomegaly
(3) syncope
(4) ischemic syndromes if coronary arteries occluded
Changes in the electrocardiogram seen in amyloidosis:
(1) low voltage in all wave forms in the limb leads (I, II, III, aVL, aVF, aVR)
(2) marked left axis deviation
(2a) left axis deviation: QRS axis from -30° to -90°
(2b) extreme left axis deviation: QRS axis from -90° to -180°
(3) absent (QS) or minimal R waves
(3a) typically in leads V1-V3 or in lead V4
(3b) sometimes loss of R waves in leads II, III and aVF
(4) conduction defects:
(4a) increased P-R interval (first degree AV block)
(4b) intraventricular conduction delay
(4c) left and/or right bundle branch block
(4d) second degree AV block
(5) arrhythmias
(5a) atrial fibrillation
(5b) ventricular premature contractions
Purpose: To identify electrocardiographic findings associated with amyloid deposits in the heart.
Specialty: Cardiology, Hematology Oncology
Objective: imaging studies, laboratory tests, criteria for diagnosis, severity, prognosis, stage
ICD-10: I43.1, E85.4,