In amyloidosis an abnormal protein is deposited in one or more organs of the body. Deposits in the heart may result in cardiomegaly, heart failure and conduction defects.
(1) congestive heart failure, especially without a history of previous heart disease
(4) ischemic syndromes if coronary arteries occluded
Changes in the electrocardiogram seen in amyloidosis:
(1) low voltage in all wave forms in the limb leads (I, II, III, aVL, aVF, aVR)
(2) marked left axis deviation
(2a) left axis deviation: QRS axis from -30° to -90°
(2b) extreme left axis deviation: QRS axis from -90° to -180°
(3) absent (QS) or minimal R waves
(3a) typically in leads V1-V3 or in lead V4
(3b) sometimes loss of R waves in leads II, III and aVF
(4) conduction defects:
(4a) increased P-R interval (first degree AV block)
(4b) intraventricular conduction delay
(4c) left and/or right bundle branch block
(4d) second degree AV block
(5a) atrial fibrillation
(5b) ventricular premature contractions
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Purpose: To identify electrocardiographic findings associated with amyloid deposits in the heart.
Specialty: Cardiology, Hematology Oncology
Objective: imaging studies, laboratory tests, criteria for diagnosis, severity, prognosis, stage
ICD-10: I43.1, E85.4,