CAR T-Cell-Related Encephalopathy Syndrome(CRES) Grading System of Neelapu et al

Description

Neelapu et al developed a grading system to evaluate a patient with CAR (chimeric antigen receptor) T-cell-related encephalopathy (CRES). The authors are from multiple instittutions in the United States and members of the CARTOX (CAR T-cell therapy associated TOXicity) working group.

Patient selection: therapy with CAR T-cell therapy

The grading is based on Common Terminology Criteria for Adverse Events (CTCAE).

Parameters:

(1) CARTOX-10 score (from 0 to 10)

(2) raised intracranial pressure

(3) seizures

(4) motor weakness

Parameter	Finding	Grade
CARTOX-10 for cognitive status	7 to 9 (mild impairment)	1
	3 to 6 (moderate impairment)	2
	0 to 2 (severe impairment)	3
	in critical condition	4
intracranial pressure	Stage 1 or 2 papilledema;	3
	Stage 3 to 5 papilledema; CSF opening pressure >= 20 mm Hg; cerebral edema	4
seizures	partial; nonconvulsive seizure on EEG that responds to benzodiazepines	3
	generalized seizures; status epilepticus	4
motor weakness	new development	4

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CAR T-Cell-Related Encephalopathy Syndrome(CRES) Grading System of Neelapu et al

Description

Specialty