Patients with advanced cancer often show the cancer cachexia syndrome. The presence of cancer cachexia is a poor prognostic sign.
Synonym: cancer anorexia-cachexia syndrome, CACS, cancer wasting syndrome
Patient selection: advanced cancer
(1) anorexia or early satiety with or without changes in taste
(2) unintended weight loss
(3) muscle loss (sarcopenia)
(4) loss of body fat
(5) systemic symptoms such as fatigue and/or evidence of systemic inflammation (elevated C-reactive protein, elevated serum cytokines)
• In pure starvation body fat is depleted while there is relative preservation of skeletal muscle.
Fearon et al used 3 factors to identify a patient with cancer cachexia:
(1) weight loss > 10%
(2) low food intake (<= 1,500 kcal per day)
(3) elevated CRP >= 10 mg/L
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Purpose: To evaluate a patient for the cancer cachexia syndrome (cancer wasting syndrome).
Specialty: Nutrition, Hematology Oncology
Objective: clinical diagnosis, including family history for genetics
ICD-10: C00-D49, R64,