Formulations of Exubera:
(1) 1 mg blister pack (with 1 raised marking)
(2) 3 mg blister pack (with 3 raised markings)
Only 1 blister can be used for each inhalation.
Drug delivery differs between the 2 types of blister packs. 3 one mg unit blisters delivers 30-40% more insulin than a single 3 mg blister.
Dosing: three times a day (TID), just prior to a meal
mg of inhaled insulin per dose =
= (0.05 * (body weight in kilograms))
where:
• The body weight used appears to be actual body weight rather than the ideal body weight (IBW).
number of 3 mg units to use =
= INTEGER(dose/3)
number of 1 mg units to use =
= ROUND((total dose) - (3 * (number of 3 mg units)))
If hypoglycemia is a problem then a lower dose should be used.
Reasons for less than an expected response:
(1) moisture in the device chamber
(2) exposure to high levels of environmental smoke
(3) improper inhalation technique
