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Calculating the Estimated Drug Clearance and Maintenance Dose in Renal Insufficiency

Specialty:

Toxicology
Emergency Medicine
Critical Care
Nephrology

Objective:

ICD-10:

Description:

For drugs in which urinary excretion is an important route of excretion, the presence of renal insufficiency or failure results in decreased drug clearance. Administering a drug by the usual dosing schedules results in accumulation of the drug and/or its metabolites, thereby increasing the risk for toxicity. Calculation of drug dosage is most accurately based on the clearance of a drug, since this is a direct measure of drug removal.

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