The aspirin converting factor (ACF) can be used to help estimate the equivalent dose of aspirin when a nonaspirin salicylate is ingested.
For a liquid formulation:
ACF =
= (molecular weight of aspirin in grams) / (molecular weight of compound in grams) * (specific gravity of the compound) * (density of water in grams per mL) =
= 180.16 / (molecular weight of compound in grams) * (specific gravity of the compound) * 0.9982
where:
• The specific gravity of water at room temperature (20°C or 68°F) is 0.9982.
• (specific gravity of the compound) * (density of water in grams per mL) = density of the compound in grams per mL
Salicylate Liquids |
Specific Gravity |
benzyl salicylate |
1.175 |
ethyl salicylate |
1.131 |
homosalate |
1.045 |
methyl salicylate |
1.184 |
octyl salicylate |
1.108 |
available in The Merck Index
For a solid formulation:
ACF =
= (molecular weight of aspirin in grams) / (molecular weight of compound in grams) =
= 180.16 / (molecular weight of compound in grams)
Specialty: Pharmacology, clinical
ICD-10: ,