The aspirin converting factor (ACF) can be used to help estimate the equivalent dose of aspirin when a nonaspirin salicylate is ingested.
For a liquid formulation:
ACF =
= (molecular weight of aspirin in grams) / (molecular weight of compound in grams) * (specific gravity of the compound) * (density of water in grams per mL) =
= 180.16 / (molecular weight of compound in grams) * (specific gravity of the compound) * 0.9982
where:
• The specific gravity of water at room temperature (20°C or 68°F) is 0.9982.
• (specific gravity of the compound) * (density of water in grams per mL) = density of the compound in grams per mL
Salicylate Liquids
Specific Gravity
benzyl salicylate
1.175
ethyl salicylate
1.131
homosalate
1.045
methyl salicylate
1.184
octyl salicylate
1.108
available in The Merck Index
For a solid formulation:
ACF =
= (molecular weight of aspirin in grams) / (molecular weight of compound in grams) =
= 180.16 / (molecular weight of compound in grams)
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