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Calculating Risk of Down's Syndrome from Maternal Serum alpha-Fetoprotein and HCG

Specialty:

Nephrology, Urology, Obstetrics & Gynecology, Pedatrics, Genetics
Nephrology, Urology, Obstetrics & Gynecology, Pedatrics, Genetics
Nephrology, Urology, Obstetrics & Gynecology, Pedatrics, Genetics

Objective:

ICD-10:

Description:

The risk of a fetus being affected by Down's syndrome can be calculated based on the maternal a priori risk consequent to age, AFP multiple of the mean, and HCG multiple of the mean. The distributions for AFP and HCG are assumed to fit a bivariate log-gaussian distribution in both normal and Down's pregnancies. AFP is typically 30% lower in Down's pregnancies, while HCG is 200% higher.

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