Creatinine dynamics can be estimated by assessing urine and serum. Typically a 24 hour urine is used for the study.


(1) urine creatinine in mg/dL

(2) urine volume in mL

(3) plasma creatinine in mg/dL

(4) time period in minutes


creatinine clearance (mL/min) =

= ((urine creatinine in mg/dL) * (urine volume in mL)) / ((plasma creatinine in mg/dL) * (time period in minutes))



• 24 hours = 1440 minutes



• It is assumed that the patient has relatively stable creatinine dynamics over the time period studied. Some patients can have fluctuating renal function sufficient to interfere with the evaluation.

• Although shorter periods of time than 24 hours can be used if needed, if the period is too short, then misleading information can be derived.

To read more or access our algorithms and calculators, please log in or register.