Creatinine dynamics can be estimated by assessing urine and serum. Typically a 24 hour urine is used for the study.
Parameters:
(1) urine creatinine in mg/dL
(2) urine volume in mL
(3) plasma creatinine in mg/dL
(4) time period in minutes
creatinine clearance (mL/min) =
= ((urine creatinine in mg/dL) * (urine volume in mL)) / ((plasma creatinine in mg/dL) * (time period in minutes))
where:
• 24 hours = 1440 minutes
Limitations:
• It is assumed that the patient has relatively stable creatinine dynamics over the time period studied. Some patients can have fluctuating renal function sufficient to interfere with the evaluation.
• Although shorter periods of time than 24 hours can be used if needed, if the period is too short, then misleading information can be derived.
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