Description

Creatinine dynamics can be estimated by assessing urine and serum. Typically a 24 hour urine is used for the study.


Parameters:

(1) urine creatinine in mg/dL

(2) urine volume in mL

(3) plasma creatinine in mg/dL

(4) time period in minutes

 

creatinine clearance (mL/min) =

= ((urine creatinine in mg/dL) * (urine volume in mL)) / ((plasma creatinine in mg/dL) * (time period in minutes))

 

where:

• 24 hours = 1440 minutes

 

Limitations:

• It is assumed that the patient has relatively stable creatinine dynamics over the time period studied. Some patients can have fluctuating renal function sufficient to interfere with the evaluation.

• Although shorter periods of time than 24 hours can be used if needed, if the period is too short, then misleading information can be derived.


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