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C-Reactive Protein (CRP) and Pro-Brain Natriuretic Peptide (NT-ProBNP) for Predicting the 1 Year Mortality Rate for a Dyspneic Patient in the ED

Description

Rehman et al evaluated dyspneic patients in the Emergency Department using C-reactive protein (CRP) and pro-Brain natriuretic peptide (NT-proBNP). They identified patients at risk for increased 1 year mortality. The authors are from Massachusetts General Hospital and Northwestern University.


 

Assays:

(1) CRP (Roche Diagnostics): reference range not stated

(2) NT-proBNP: neither method nor reference range stated but reference made to the PRIDE study

 

Parameters from multivariate analysis with significant hazard ratios and low p values::

(1) CRP in mg/L

(2) NT-proBNP

(3) heart murmur

 

Parameter

Finding

Points

CRP

< 14 mg/L

0

 

>= 14 mg/L

1

NT-proBNP

<= 986 ng/L

0

 

> 986 ng/L

1

murmur on examination

absent

0

 

present

1

 

number of risk factors =

= SUM(points for the 3 parameters)

 

Interpretation:

• minimum number of risk factors: 0

• maximum number of risk factors: 3

• The greater the number of risk factors the greater the 1 year mortality rate.

 


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Specialty

Objective

ICD-10