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Advanced Cancer Vitamin B12 to C-Reactive Protein (CRP) Ratio

Purpose: To identify a patient with advanced cancer who has a poor prognosis using the Vitamin B12 to CRP ratio (B12 CRP Index or BCI).

Description

Geissbuhler et al used the ratio of serum vitamin B12 to C-reactive protein (CRP) to identify a patient with advanced cancer who has poor prognosis and a short survival.


 

Parameters:

(1) serum vitamin B12 in pmol/L

(2) C-reactive protein in mg/L

 

vitamin B12 / C-reactive protein index = BCI =

= (vitamin B12) / (CRP)

 

Interpretation:

• Geissbuhler et al found that a BCI > 40,000 is associated withi a 3 month (90 day) survival rate of 9.4%.

• Kelly et al found that a BCI > 40,000 is associated with a poor prognosis, with a median survival of 29 days.

 


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Specialty

Objective

ICD-10