Olszewski et al reported the Burkitt Lymphoma International Prognostic Index (BL-IPI) for evaluation of patients with Burkitt Lymphoma. The authors are from around the world and are members of the Burkitt Lymphoma International Prognostic Index consortium.
Patient selection: Burkitt Lymphoma (BL)
Parameters:
(1) age in years
(2) ECOG performance status
(3) serum lactate dehydrogenase in U/L, versus upper limit of normal (ULN)
(4) CNS involvement
Parameter
Finding
Points
age in years
< 40 years
0
>= 40 years
1
ECOG performance
0 or 1
0
2, 3 or 4
1
serum LDH
<= 3 times ULN
0
> 3 times ULN
1
CNS involvement
no
0
yes
1
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
Total Score
Risk Group
3-Year Overall Survival
0
low
96%
1
intermediate
76%
2 to 4
high
59%
Performance:
• The area under the ROC curve was 0.64 for progression-free survival and 0.66 for overall survival.
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