Patient selection: primary or secondary hyperparathyroidism
Common locations: long bones, pelvic girdle, clavicle, ribs, mandible
The patient may have multiple bone lesions.
Gross appearance:
(1) brown color (from hemosiderin)
(2) partially cystic, partially solid
Histologic appearance:
(1) numerous osteoclast-like multinucleated giant cells
(2) fibroblastic stroma that is hypervascular
(3) hemosiderin-laden macrophages
Differential diagnosis:
(1) other bone lesions with giant cells
Misdiagnosis can occur if the presence of hyperparathyroidism is not recognized.
