Patient selection: older adult (median age 85 years)
Parameters:
(1) hyperlipidemia
(2) number of medications
(3) length of hospital stay in days
(4) use of anti-diabetic agent
(5) WBC cell count on admission
|
Parameter
|
Finding
|
Points
|
Beta-Coefficient
|
|
hyperlipidemia
|
absent
|
0
|
0
|
|
|
present
|
1
|
1.199
|
|
number of meds
|
< 8
|
0
|
0
|
|
|
>= 8
|
1
|
1.194
|
|
length of stay
|
< 12 days
|
0
|
0
|
|
|
>= 12 days
|
1
|
0.819
|
|
anti-diabetic drugs
|
no
|
0
|
0
|
|
|
yes
|
1
|
0.645
|
|
WBC count
|
not high
|
0
|
0
|
|
|
high
|
1
|
0.437
|
where:
• The cutoff for a high white blood cell count was not stated.
total score =
= SUM(points for all 5 parameters)
value of X =
= SUM(all 5 beta-coefficients) - 3.628
probability of an adverse drug reaction =
= 1 / (1 + EXP((-1) * X))
Interpretation:
• minimum score: 0
• maximum score: 5
• The higher the score the greater the risk of an adverse drug reaction.
• The maximum Youden index is for a score > 1.
Performance:
• The area under the ROC curve is 0.73.
