Widell et al used a simple score to describe the degree of dysplasia in the bone marrow of patients with myelodysplasia. The authors are from Karolinska, Huddinge and Danderyd Hospitals in Stockholm.
Parameters:
(1) granulocytic dysplasia: (a) hypogranulation and (b) pseudo-Pelger-Huet
(2) erythrocytic dysplasia: (a) megaloblastic changes and (b) multi-nuclearity or abnormal nuclei
(3) megakaryocytic dysplasia: (a) small megakaryocytes and (b) hypolobed megakaryocytic nuclei
|
Parameter |
Finding |
Points |
|
hypogranulation |
none to rare |
0 |
|
|
few to some |
1 |
|
|
many to most |
2 |
|
pseudo-Pelger-Huet |
none to rare |
0 |
|
|
few to some |
1 |
|
|
many to most |
2 |
|
megaloblastic changes |
none to rare |
0 |
|
|
few to some |
1 |
|
|
many to most |
2 |
|
multi-nuclearity or abnormal nuclei |
none to rare |
0 |
|
|
few to some |
1 |
|
|
many to most |
2 |
|
small megakaryocytes |
none to rare |
0 |
|
|
few to some |
1 |
|
|
many to most |
2 |
|
hypolobed megakaryocytic nuclei |
none to rare |
0 |
|
|
few to some |
1 |
|
|
many to most |
2 |
subscore for granulocytic dysplasia =
= (points for hypogranulation) + (points for pseudo-Pelger Huet)
subscore for granulocytic dysplasia =
= (points for hypogranulation) + (points for pseudo-Pelger Huet)
subscore for granulocytic dysplasia =
= (points for hypogranulation) + (points for pseudo-Pelger Huet)
total dysplastic score =
= SUM(points for dysplasia scores in the 3 lineages)
Interpretation:
• minimum subscore: 0
• maximum subscore: 4
• minimum total dysplastic score: 0
• maximum total dysplastic score: 12
• A total score < 6 was considered a low degree of bone marrow dysplasia, while a total score >= 6 was considered a high degree of bone marrow dysplasia.
Specialty: Hematology Oncology, Clinical Laboratory
ICD-10: ,
