Widell et al used a simple score to describe the degree of dysplasia in the bone marrow of patients with myelodysplasia. The authors are from Karolinska, Huddinge and Danderyd Hospitals in Stockholm.
(1) granulocytic dysplasia: (a) hypogranulation and (b) pseudo-Pelger-Huet
(2) erythrocytic dysplasia: (a) megaloblastic changes and (b) multi-nuclearity or abnormal nuclei
(3) megakaryocytic dysplasia: (a) small megakaryocytes and (b) hypolobed megakaryocytic nuclei
none to rare
few to some
many to most
multi-nuclearity or abnormal nuclei
hypolobed megakaryocytic nuclei
subscore for granulocytic dysplasia =
= (points for hypogranulation) + (points for pseudo-Pelger Huet)
total dysplastic score =
= SUM(points for dysplasia scores in the 3 lineages)
• minimum subscore: 0
• maximum subscore: 4
• minimum total dysplastic score: 0
• maximum total dysplastic score: 12
• A total score < 6 was considered a low degree of bone marrow dysplasia, while a total score >= 6 was considered a high degree of bone marrow dysplasia.
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Specialty: Hematology Oncology, Clinical Laboratory