One of the skeletal manifestations of Gaucher disease is bone crises.


Synononym: pseudo-osteomyelitis


Patient selection: Gaucher disease


Clinical features of a bone crisis:

(1) acute onset of severe skeletal pain

(2) fever

(3) leukocytosis

(4) elevated erythrocyte sedimentation rate (ESR) or C-reactive protein

(5) negative blood and bone cultures


Imaging findings:

(1) periosteal elevation on routine X-ray

(2) photopenia on radionuclide bone scan

(3) increased T2-weighted signal on MRI


To read more or access our algorithms and calculators, please log in or register.