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Blood Lactate and Survival in Critically Ill Patients

Description

Critically ill patients develop tissue hypoxia with lactic acidosis and high blood lactate levels. High lactate levels can correlate with the patient's prognosis.


 

Parameters:

(1) lactate in mmol/L (conversion factor from mg/dL to mmol/L is 0.111)

(2) urine output in mL per 8 hour period

(3) qualitative severity rating, from 1 (good) to 5 (very bad)

 

Survivor if:

False NonSurvivor

False Survivor

lactate in mmol/L <= 3.830

0.04

0.49

((5.649 * LOG10 (lactate)) - (0.0008 * (urine output))) <= 3.040

0.05

0.41

((4.592 * LOG10 (lactate)) + (1.073 * (severity rating))) <= 6.409

0.03

0.44

((4.456 * LOG10 (lactate)) - (0.0009 * (urine output))+ (1.087 * (severity rating))) <= 6.002

0.05

0.44

 

 

Approximating the survival curve in Figure 7 (Weil, 1973) with JMP,

 

lactate in mmol/L

probability of survival =

< 0.7

100%

0.7 to 3.0

(0.0005149 * ((lactate)^3)) - (0.026797 * ((lactate) ^ 2)) + (0.0082298 * (lactate)) + 0.9992159

3.0 to 6.0

(0.0314286* ((lactate) ^ 2)) - (0.467143 * (lactate)) + 1.9214286

6.0 to 20

(0.0000303 * ((lactate)^4)) - (0.001872 * ((lactate)^3)) + (0.0425701 * ((lactate) ^ 2)) - (0.427473 * (lactate)) + 1.6471193

> 20

0%

 


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