Blepharospasm-Oromandibular Dystonia (Meige’s Syndrome) is a rare dystonia syndrome that can be a challenge to diagnose.
Key clinical features:
(1) blepharospasm
(2) oromandibular dystonia (dystonic spasms/contractions of facial muscles and jaw muscles)
Additional findings:
(1) dry eye, which may be poorly-responsive to routine therapy
(2) spasm of neck and limb muscles
(3) action tremor
Risk factors:
(1) therapy with typical antipsychotic drugs (olanzapine, other)
(2) therapy with levodopa
(3) focal brain lesions (basal ganglia, diencephalon, brainstem)
(4) neurodegenerative disorder
Differential diagnosis:
(1) psychiatric disorder
(2) hemifacial spasm
