Chronic lymphocytic leukemia (CLL) is a slowly progressive disease tending to affect the elderly. While initially manifesting itself usually as a lymphocytosis, as the course progresses there may be lymphadenopathy, hepatosplenomegaly, anemia and thrombocytopenia. Binet et al developed a staging system which correlates with survival.
Stage
Clinical Feature
Survival (months)
A
hemoglobin >= 10 g/dL
platelet count >= 100,000/µL
< 3 areas involved
> 120
B
hemoglobin >= 10 g/dL
platelet count >= 100,000/µL
>= 3 areas involved
61
C
(hemoglobin < 10 g/dL) OR
(platelet count < 100,000 µL)
32
where areas of involvement are:
(1) cervical lymph nodes
(2) axillary lymph nodes
(3) inguinal lymph nodes
(4) liver
(5) spleen
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