The ratio of serum beta2-microglobulin to the lymphocyte count may have prognostic significance.

Beta2-microglobulin is light chain subunit of major histocompatibility complex I antigens is present on the surface of all nucleated cells.



(1) beta2-microglobulin concentration in mg/L

(2) absolute lymphocyte count in 10^9/L


beta2-microglobulin to absolute lymphocyte ratio =

= (beta2-microglobulin) / (absolute lymphocyte count)



• For patients with nasal type extranodal NK/T cell lymphoma a ratio > 4.87 was associated with worse prognosis.

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