Platelet specific proteins include beta-thromboglobulin, platelet factor 4, platelet-derived growth factor and thrombospondin. They are contained within the platelet alpha granules but are absent in the plasma of normal individuals. The ratio of beta-thromboglobulin-to-platelet factor 4 can be used as a measure of platelet activation, with an increase in the ratio being seen during activation of platelets in vivo.

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