A patient with beta-thalassemia may be asymptomatic or not, depending on what genes have been inherited. The severity of the anemia correlates with complications.
(1) severity of anemia
(2) mean cell volume (MCV)
(4) bone lesions
(5) transfusion requirements
(6) iron overload
none to mild
mild to moderate
variable, may be normal
may be present or absent
does not require regular transfusion
may be present
asymptomatic to severely symptomatic
Hemoglobin E Thalassemia
mild to severe
present, may be less severe if regularly transfused
significant and lifelong; requires regular transfusion
mild to significant
dependent on transfusion requirements
A person may be reclassified as thalassemia intermedia following splenectomy if regular transfusions are no longer required.
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Purpose: To determine the clinical syndrome experienced by a patient with beta-thalassemia.
Specialty: Hematology Oncology, Clinical Laboratory, Genetics
Objective: clinical diagnosis, including family history for genetics
ICD-10: D56, D56.1,