A patient may develop hypertension if an antihypertensive drug is discontinued.


Drugs that may show a rebound hypertension:

(1) beta-blockers (beta-adrenergic receptor blocking agents)

(2) methyldopa, clonidine or other centrally-acting alpha-receptor agonist


Clinical features:

(1) long-term therapy with the implicated drug (long-term beta-blocker therapy is associated with an increase in beta-adrenergic receptors)

(2) abrupt discontinuation

(3) normalization of the blood pressure once the body adjusts


Differential diagnosis:

(1) Discontinuation of a drug that is used to control hypertension can result in reappearance of the hypertension. In this case the elevated blood pressure persists.


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