The heart contains both beta-1 and beta-2 adrenergic receptors. Nonselective or selective beta-adrenergic agents can have adverse cardiovascular effects.
Groups given selective beta-2 agonists to provide bronchodilation:
(1) bronchial asthma
(2) chronic obstructive pulmonary disease
Cardiovascular effects of a beta-adrenergic agonist may include:
(1) sinus tachycardia, atrial fibrillation, ventricular tachycardia, or other tachyarrhythmia
(2) acute myocardial infarction
(3) congestive heart failure
(5) cardiac arrest or sudden cardiac death
Risk factors for adverse cardiovascular effect:
(1) high dose of the beta-agonist
(2) frequent dosing of the beta-agonist
(3) underlying cardiovascular disease
(4) interacting drugs that interfere with the beta-agonist metabolism or otherwise heighten its response
(5) exposure to other stimulants (excessive thyroid hormone, amphetamines, cocaine, etc)
(6) new user
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Purpose: To identify a patient who may be at risk for an adverse cardiovascular effect of a beta-agonist drug.
Specialty: Cardiology, Pharmacology, clinical
Objective: options, selection, adverse effects, complication detection