Benedict et al reported the RAW (Resistant Alcohol Withdrawal) score for predicting the risk of benzodiazepine-resistant withdrawal. The authors are from the University of Pittsburgh and affiliated hospitals.
Patient selection: alcohol withdrawal
Outcome: benzodiazepine resistance (need for >= 40 mg of diazepam in 1 hour)
Parameters:
(1) history of psychiatric illness
(2) Charlson comorbidity index (CCI) within 24 hours of admission
(3) SAPS II score, from 0 to 160
(4) liver function tests (LFTs) on admission
(5) sex
(6) race
(7) platelet count in 10^9/L
|
Parameter
|
Finding
|
Points
|
|
psychiatric history
|
no
|
0
|
|
|
yes
|
0.70
|
|
Charlson comorbidity
|
|
-0.26 * (CCI)
|
|
SAPS II
|
|
-0.04 * (SAPS II)
|
|
liver function tests
|
normal
|
0
|
|
|
abnormal (not defined)
|
0.5
|
|
sex
|
male
|
0.95
|
|
|
female
|
0
|
|
race
|
Caucasian
|
1.28
|
|
|
other
|
0
|
|
platelet count
|
>= 150 * 10^9/L
|
0
|
|
|
< 150 * 10^9/L (thrombocytopenia)
|
0.76
|
value of X =
= SUM(points for all of the parameters) - 2.81
probability of resistant alcohol withdrawal =
= 1 / (1 + EXP((-1) * X))
Perfornance:
• The area under the ROC curve is 0.74.
