Tefferi et al reported a risk categories for myelodysplasia that can be used at a point-of-care. The authors are from the Mayo Clinic.
Patient selection: myelodysplastic syndrome
Parameters:
(1) karyotype
(2) red cell transfusions
(3) percent blasts in the bone marrow
(4) age in years
Low risk - all 3 of the following:
(1) low risk karyotype (normal, 5q-)
(2) no red blood cell transfusions
(3) bone marrow blasts < 10%
High risk - all 3 of the following:
(1) intermediate or high risk (monosomal) karyotype
(2) red cell transfusions dependent
(3) bone marrow blasts >= 10%
High risk - high risk karyotype and one of the following:
(1) red cell transfusions dependent
(2) bone marrow blasts >= 10%
Intermediate risk: not classified as low or high risk
|
Risk Group
|
Median Survival
|
Age <= 70 Years
|
Age > 70 Years
|
|
low
|
70 months
|
104 months
|
54 months
|
|
intermediate
|
22 months
|
25 months
|
20 months
|
|
high
|
4.2 months
|
7 months
|
4 months
|
