Thrombocytopenia on human chromosome 10 (THC2) is a hereditary bleeding disorder associated with a defect in development of megakaryocytes.


Chromosome location: 10p11-12 (possibly affecting FLJ14813 and MASTL)


Inheritance: autosomal dominant


Clinical features:

(1) mild bleeding disorder


Laboratory findings:

(1) thrombocytopenia

(2) .A bone marrow biopsy shows incomplete differentiation of megakaryocytes with mature forms absent or reduced.


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