The different types of autoimmune myositis may be associated with different autoantibodies.
Polymyositis
Autoantibody |
Target |
Also Found In |
anti-ARS (anti-Jo1, anti-Ha, others) |
tRNA synthetase |
antisynthetase syndrome |
Dermatomyositis
Autoantibody |
Target |
Also Found In |
anti-Mi-2 |
NuRD subunit |
|
anti-TIFI-gamma |
transcriptional intermediary factor 1gamma |
paraneoplastic DM |
anti-NXP-2 |
nuclear matrix protein 2 |
paraneoplastic DM |
anti-MDA5 |
melanoma dedifferentiation associated protein 5 |
ILD |
anti-SAE |
SUMO-1 activating enzyme |
|
Necrotizing Myopathy
Autoantibody |
Target |
Also Found In |
anti-SRP |
signal recognition particle |
|
anti-HMGCR |
3-hydroxy-3-methyl-glutaryl-CoA reductase |
statin use |
Overlap with Polymyositis/Dermatomyositis
Autoantibody |
Target |
Also Found In |
anti-Ro/SSA |
Ro52 subunit |
SLE, Sjogren's |
anti-PM/Scl |
|
scleroderma |
anti-Ku |
|
SLE, Sjogren's, ILD |
anti-U1RNP |
|
LE, MCTD |
Specialty: Immunology/Rheumatology