The different types of autoimmune myositis may be associated with different autoantibodies.
Polymyositis
Autoantibody
Target
Also Found In
anti-ARS (anti-Jo1, anti-Ha, others)
tRNA synthetase
antisynthetase syndrome
Dermatomyositis
anti-Mi-2
NuRD subunit
anti-TIFI-gamma
transcriptional intermediary factor 1gamma
paraneoplastic DM
anti-NXP-2
nuclear matrix protein 2
anti-MDA5
melanoma dedifferentiation associated protein 5
ILD
anti-SAE
SUMO-1 activating enzyme
Necrotizing Myopathy
anti-SRP
signal recognition particle
anti-HMGCR
3-hydroxy-3-methyl-glutaryl-CoA reductase
statin use
Overlap with Polymyositis/Dermatomyositis
anti-Ro/SSA
Ro52 subunit
SLE, Sjogren's
anti-PM/Scl
scleroderma
anti-Ku
SLE, Sjogren's, ILD
anti-U1RNP
LE, MCTD
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Specialty: Immunology/Rheumatology
