Aspirin Triad Syndrome

Some patients with hypersensitivity to aspirin may show the aspirin "triad".

Findings of the aspirin "triad":

(1) aspirin intolerance

(2) chronic rhinosinusitis with nasal polyposis

(3) bronchial asthma

Additional findings:

(1) naso-ocular symptoms (profound nasal congestion, rhinorrhea, ocular injection)

(2) high rate of orbital complications

(3) eosinophilia in nasal secretions

(4) sensitivity to tartrazine (FD&C Yellow No. 5)

Differential diagnosis:

(1) infectious sinusitis

(2) allergy to other agent

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Purpose: To determine if a patient is reacting to aspirin with the aspirin triad syndrome.