Intravenous infusion of immune globulin may occasionally result in aseptic meningitis. Identification of risk factors with modification in administration can allow continued therapy.


Manifestations - transient, lasting 3-5 days:

(1) headache - range from mild to severe

(2) meningismus with nuchal rigidity

(3) photophobia and/or painful eye movements

(4) fever

(5) drowsiness or lethargy

(6) nausea and vomiting


Laboratory findings in CSF:

(1) polymorphonuclear pleocytosis (up to 1,200 per µL)

(2) increased protein (up to 100 mg/dL = 1 g/dL)

(3) normal glucose

(4) sterile cultures


Risk factors:

(1) history of migraine

(2) dose and rate dependent - high doses (>= 1 g/kg) administered over a short period (within 24 hours)



(1) slow the infusion rate

(2) use analgesics to treat symptoms of headache


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