Manifestations - transient, lasting 3-5 days:
(1) headache - range from mild to severe
(2) meningismus with nuchal rigidity
(3) photophobia and/or painful eye movements
(4) fever
(5) drowsiness or lethargy
(6) nausea and vomiting
Laboratory findings in CSF:
(1) polymorphonuclear pleocytosis (up to 1,200 per µL)
(2) increased protein (up to 100 mg/dL = 1 g/dL)
(3) normal glucose
(4) sterile cultures
Risk factors:
(1) history of migraine
(2) dose and rate dependent - high doses (>= 1 g/kg) administered over a short period (within 24 hours)
Interventions:
(1) slow the infusion rate
(2) use analgesics to treat symptoms of headache
