The American Society of Clinical Oncology (ASCO) has reviewed complications associated with immune checkpoint inhibitor therapy, including renal involvement.
Patient selection: acute kidney injury (AKI) or nephritis following therapy with immune checkpoint inhibitor
Parameters:
(1) serum creatinine in mg/dL
(2) therapy required
(3) life-threatening
Serum Creatinine
Therapy
Life-Threatening
Grade
1.5 to 2 times baseline; increase GT 0.3 mg/dL
outpatient
no
G1
2 to 3 times baseline
outpatient
no
G2
3.01 to 6 times baseline; > 4.0 mg/dL
hospitalization
no
G3
> 6 times baseline
dialysis; ICU
yes
G4
Other causes of renal injury (drugs, infection, vascular) should be excluded.
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