The American Society of Clinical Oncology (ASCO) has reviewed complications associated with immune checkpoint inhibitor therapy.
Patient selection: peripheral neuropathy following therapy with an immune checkpoint inhibitor
Parameters:
(1) signs and symptoms
(2) cranial nerve involvement
(3) activities of daily living (ADL)
|
Signs and Symptoms
|
Cranial Nerve Involvement
|
Activities of Daily Living
|
Grade
|
|
mild
|
none
|
no interference
|
G1
|
|
mild
|
present
|
no interference
|
G2
|
|
moderate; no weakness or gait limitation
|
NA
|
some interference
|
G2
|
|
severe; weakness; gait problems; respiratory problems
|
NA
|
limited self-care
|
G3/G4
|
The diagnosis requires exclusion of other causes of peripheral neuropathy.
