The American Society of Clinical Oncology (ASCO) has reviewed complications associated with immune checkpoint inhibitor therapy.
Patient selection: encephalitis following therapy with an immune checkpoint inhibitor
Parameters:
(1) signs and symptoms
(2) cranial nerve involvement
(3) activities of daily living
|
Signs and Symptoms
|
Cranial Nerve Involvement
|
Activities of Daily Living
|
Grade
|
|
none or mild
|
none
|
normal function
|
G1
|
|
moderate, no gait limitation or weakness
|
none or present
|
some interference
|
G2
|
|
severe
|
none or present
|
limited self-care
|
G3
|
|
life-threatening
|
NA
|
NA
|
G4
|
The diagnosis requires exclusion of other causes of encephalitis, especially infection and paraneoplastic.
