The American Society of Clinical Oncology (ASCO) has reviewed complications associated with immune checkpoint inhibitor therapy.
Patient selection: adrenal insufficiency following therapy with an immune checkpoint inhibitor
Parameters:
(1) symptoms
(2) functional ability
|
Symptoms
|
Functional Ability
|
Grade
|
|
none or mild
|
normal
|
G1
|
|
moderate
|
able to perform ADL
|
G2
|
|
severe
|
NA
|
G3/G4
|
|
life-threatening
|
NA
|
G3/G4
|
|
NA
|
unable to perform ADL
|
G3/G4
|
The diagnosis requires exclusion of other causes of adrenal insufficiency such as metastases.
