Indications to Change an Antiretroviral Therapeutic Regimen

Is the regimen a double nucleoside regimen (2 NRTI)?

Number of weeks on the regimen

CD4+ T cell count per µL just before starting therapy

HIV RNA copies per mL just before starting therapy

HIV RNA copies per mL at 8 weeks after starting therapy

Repeated HIV RNA copies per mL at 24 weeks after starting therapy

Repeated HIV RNA copies per mL at 48 weeks after starting therapy

Nadir HIV RNA

Current HIV RNA

Repeat HIV RNA

Has the patient had persistently declining CD4+ T cell numbers measured on at least 2 separate occasions?

Current CD4+ T cell count

Has the patient had disease progression with clinical deterioration while on the regimen?

Has the patient developed unacceptable side effects?

Is the regimen too complex for the patient to adhere to?