Apparent mineralocorticoid excess (AME) is a form of hereditary hypertension that is cortisol-mediated.
Inheritance: autosomal recessive
Mutation: Type 2 isoenzyme of 11-beta hydroxysteroid dehydrogenase
Effect: reduced activity, with decreased metabolism of cortisol to cortisone
(2) low plasma renin and aldosterone concentrations
(3) normal serum cortisol level with increased half life
(4) increased ratio of urine cortisol to cortisone in a 24 hour urine
(5) therapeutic response to high doses of spironolactone or amiloride
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Purpose: To evaluate a patient with hypertension for apparenent mineralocorticoid excess (AME).
Specialty: Endocrinology, Clinical Laboratory, Nephrology, Cardiology
Objective: criteria for diagnosis