Apparent Mineralocorticoid Excess (AME)

Does the patient have family members with hypertension in an autosomal recessive pattern of inheritance?

Is the plasma level of renin low?

Is the plasma level of aldosterone low?

Is the level of plasma cortisol normal?

Is the ratio of urine cortisol to cortisone in a 24 hour urine increased?

Are high doses of spironolactone or amiloride needed to control the hypertension?