Any drug associated with withdrawal reactions in an adult can cause withdrawal in an infant. This includes paroxetine or other selective serotonin reuptake inhibitors (SSRIs).


Clinical features:

(1) The mother is taking an antidepressant during the third trimester of pregnancy and/or while breastfeeding.

(2) The neonate develops a discontinuation syndrome following delivery or if breastfeeding is interrupted.

(3) Other conditions that could explain the findings are excluded.


Features of the discontinuation syndrome may include:

(1) irritability or agitation

(2) tremors

(3) tachypnea and/or respiratory distress

(4) decerebrate posturing

(5) convulsions

(6) inconsolable crying

(7) problems eating

(8) problems sleeping


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