Savoldi et al evaluated antibiotic resistance in Helicobacter pylori. Antibiotic resistance is common for Helicobacter pylori, but the susceptibility pattern varies with the global region.
Antibiotic resistance should be suspected when there is failure of antibiotic therapy without alternative explanation (noncompliance, etc).
Therapeutic History
Resistance
prior to start of first eradication therapy
primary
>= 1 unsuccessful eradication attempt
secondary
Resistance was considered high when present in >= 15% of isolates.
Antibiotics with a high prevalence of resistance:
(1) clarithromycin
(2) metronidazole
(3) levofloxacin
Antibiotics with low prevalence of resistance currently:
(1) amoxicillin
(2) tetracycline
Susceptibility testing should be considered:
(1) if starting an antibiotic that has a high prevalence of resistance in the global region
(2) if an eradication attempt has proven unsuccessful
To read more or access our algorithms and calculators, please log in or register.
