Patients with Guillain-Barre Syndrome (GBS) and related disorders may have anti-ganglioside antibodies in their serum. Neurological sites involved by the disease are often rich in the target gangliosides.


The most common antibody is anti-GQ1b.


However, other antiganglioside antibodies may also be present:

(1) anti-GM1

(2) anti-GM2

(3) anti-GD1a

(4) anti-GalNAc-GD1a

(5) anti-GD1b

(6) anti-GT1b


The presence of one or more of the antibodies supports the diagnosis of GBS spectrum disorder.


If anti-GQ1b is absent, then it is important to test for the other antibodies before reaching any conclusion.


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