A patient with Sjogren’s Syndrome may develop reduced sweating. The targeting of eccrine sweat glands by lymphocytes has been termed autoimmune anhidrosis.


Patient selection: Sjogren’s syndrome


Clinical features:

(1) decreased or absent sweating

(2) dry skin

(3) heat or exercise intolerance

(4) intolerance of direct sunlight

(5) decreased sweating a challenge with methacholine (a nonselective muscarinic receptor agonist)


A skin biopsy will show a lymphoplasmacytic infiltrate of eccrine sweat glands and their ducts.


The diagnosis requires exclusion of other causes for the hypohidrosis/anhidrosis.


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