Hereditary nephrogenic diabetes insipidus (DI) is a rare condition that can be a challenge to manage in the perioperative period.



(1) dehydration, especially if made NPO (nil per ora)

(2) handling the urine output, especially if urinary retention develops



(1) Use of normal saline (0.9% NaCl) can result in hypernatremia.

(2) The patient should receive his or her normal oral intake of water as 2.5% dextrose in water (D2.5W)

(3) Drug therapy to reduce polyuria such thiazide with (amiloride or indomethacin).

(4) Carefully monitoring fluid balance, recording input and output.


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