The type of protein deposited determines the type of amyloidosis.
Methods of analysis:
(1) immunofluorescence or immunohistochemistry (including anti-light chain antibodies)
(2) mass spectroscopy
(3) immunoelectron microscopy
Common Type of Amyloidosis
Protein
secondary
serum amyloid A
dialysis-related
beta-2 microglobulin
monoclonal protein
light chain, heavy chain
renal amyloidosis
leukocyte chemotactic factor 2
Hereditary Amyloidosis
transthyretin
fibrinogen A alpha chain (Afib)
lysozyme variants
Gelsolin variants
apolipoprotein AIV
Uncommon Types of Amyloid
amyloidosis of aging
apolipoprotein AIV, ATTR wild type
localized to seminal vesicles
semengelin
injection site (iatrogenic)
insulin, enfurvitide
endocrine
hormones
cerebral
beta, PrP, other
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Specialty: Hematology Oncology
