Amyloid may be deposited in thyroid gland.

Clinical features:

(1) diffuse painless enlargement of the thyroid gland, which may be mistaken for goiter

(2) evidence of amyloidosis elsewhere (renal, cardiac, etc)


On cytology clumps of amorphous material may be seen which can be mistaken for collagen. The diagnosis can be made if a Congo red stain is performed.


Underlying causes:

(1) primary amyloidosis

(2) amyloidosis secondary to chronic inflammation


Amyloid may also be found in medullary carcinoma of the thyroid gland.

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