A patient with amyloidosis may show joint involvement caused by deposition of the monoclonal protein.

Clinical features:

(1) seronegative symmetric polyarthritis with swelling and decreased range of motion in small and large joints

(2) absence of inflammatory findings in the joints (no erythema, tenderness or warmth)

(3) other stigmata of amyloidosis such as carpal tunnel syndrome, macroglossia, heart failure or renal disease


The diagnosis of amyloidosis may be delayed if:

(1) the joint involvement is the presenting sign

(2) the patient is misdiagnosed with another condition such as degenerative arthritis

(3) measurement of serum light chains is not performed

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