The American Society for Apheresis (AFSA) listed s number of indications for urgent plasma exchange.


Category I indications – clearly appropriate:

(1) thrombotic thrombocytopenic purpura (TTP)

(2) hyperviscosity syndrome (leukocyte, platelets, monoclonal protein)

(3) myasthenia gravis

(4) acute inflammatory demyelinating polyneuropathy


Category II indications:

(1) catastrophic antiphospholipid syndrome

(2) intoxication with drug or toxin with a favorable distribution


Category III indications – may be appropriate in selected patients:

(1) severe acute pancreatitis secondary to hypertriglyceridemia

(2) acute fulminant hepatitis


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