Smolej et al proposed an alternative score to the International Prognostic Score of Condoluci et al for a patient with asymptomatic early-stage chronic lymphocytic leukemia. The authors are from multiple institutions in the Czech Republic.
Patient selection: asymptomatic early-stage CLL (Binet A)
Parameters:
(1) IGHV mutation status
(2) absolute lymphocyte count (ALC) in 10^9/L
(3) del(11q)/del(17p)
Parameter
Finding
Points
IGHV status
mutated
0
unmuatated
1
ALC
<= 15 * 10^9/L
0
> 15 * 10^9/L
1
del(11q)/del(17p)
no
0
yes
1
where:
• Usage suggests that del(11q)/del(17p) refers to the presence of one or both of the deletions.
score =
= SUM(points for all 3 parameter)
Interpretation:
• minimum score: 0
• maximum score: 3
Score
Risk
Cumulative 5-Year Risk Therapy Initiation
0
low
14%
1
intermediate
40%
2 or 3
high
72%
Performance:
• The area under the ROC curve is 0.71.
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